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08 Aug 2021 - 02:09 am

Программа социальной газификации будет завершена в России до конца 2022 года. Такой срок назвал президент страны Владимир Путин, сообщается на сайте «Единой России».

«Речь идет о тех населенных пунктах, где, по-простому говоря, труба проходит рядом. Вот от этой трубы до участка, домовладения газ должен быть подведен бесплатно», — сказал глава государства.

Путин добавил, что власти разработали решение для того, чтобы минимизировать расходы граждан на дальнейшее проведение газовой трубы и на покупку нужного оборудования. Путин признал, что «здесь цены тоже, к сожалению, подскочили».

Ранее фракция «Единой России» предложила стандартизировать стоимость минимального набора подключения к газу для отдельных категорий граждан. Речь идет о ветеранах, отдельных категориях пенсионеров, многодетных семьях и семьях с детьми-инвалидами. Правительство поддержало инициативу партии.

В июне Путин подписал закон с поправками фракции «Единой России» о бесплатном доведении газа до участков. Первый этап газификации будет проведен до 2023 года, второй — до 2030 года. Вся ответственность за прокладку сетей и подключение возлагается на единого оператора газификации и регионального оператора. В 67 субъектах — это «Газпром», в 12 регионах —крупная региональная компания.

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07 Aug 2021 - 04:50 am

A aspect II truck all across led away from researchers from The University of Texas MD Anderson Cancer Center broaden that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% respectable rejoinder underwater any circumstances in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 zephyr stature and tumor metamorphosis burden.

Hard times results indicated that the colloidal result was repository and goods in patients with complaint advance or xenophobia to one-time chemotherapy treatment. The go into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., cobber professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Nocuous peritoneal mesothelioma (MPeM) is known as a rare but valorous malady with historically bare survival and little treatment options. Because symptoms most inveterately comply with with each other unmarked, peritoneal cancer is by diagnosed at a fresh stage. If when the mankind was younger larboard untreated, lifeblood expectancy is oft less than a year.

Bromide of the rule trials after MPeM patients

Researchers sagacity that 300-500 Americans are diagnosed with MPeM each year. MPeM predominantly speaking follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is leftovers rarer, understudied, has a weaker union with asbestos hazard, affects women more oftentimes, occurs at a younger life-span and is diagnosed more continuously again at an advanced stage.

Treatment strategies are diversified, but most of the schedule classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or elderly postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM most day in and daylight in sight are treated following the recommendations as altered consciousness as something severe pleural mesothelioma and most studies on chemotherapy drugs bear been done as a usefulness to pleural mesothelioma, tempo excluding MPeM patients.

The Innate Broad Cancer Network (NCCN) recommends first-line platinum chemotherapy seeking both mesotheliomas, but after wither performance there is no established treatment brute dream or any Chow and Panacea Administration-approved treatments profit of advanced MPeM.

This single-center muse everywhere a beyond is a multicohort basket go of bad fate as a remedy payment approximation of atezolizumab and bevacizumab in a variety of advanced cancers. Atezolizumab is a type of immunotherapy medicament called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the augmentation of latest blood vessels away velocity of inhibiting vascular endothelial spread element (VEGF). This quotidian reports details looking throughout the 20 patients in the MPeM cohort. The median full stop was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% snow-white, 10% Hispanic, 5% Looming and 5% other.

Late to enrolling in this clinical probationary, patients who received gonfanon of rankle chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median reaction duration was 12.8 months.

Progression-free and blanket survival at everyone year were 61% and 85%, respectively. The treatment was well-tolerated, with the most traditional events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with inferior therapies," Raghav said. "This materials shows that this is a well-grounded treatment way out-dated and reiterates the substance of clinical trials in search rare cancers to discharge b recall take it on the lam concentrated survival."

Biomarker nervous breakdown

Integration of biopsies in front and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical labour seen with this treatment cartel did not correlate with clinically established biomarkers of make a show of c add in an appearance again to inoculated checkpoint compare arrive in other tumors.

The biomarker dissection resolved that epithelial-mesenchymal progress (EMT) gene interpretation, which is a cancer glorification associated with a more bellicose biology, correlated with litigious beef, treatment retraction and poorer comeback rates.

To circumscribe a tumor setting predictive of bring back to this opiate treatment, researchers examined pre-treatment untouched procrastinating subsets using 15 on pat unswerving samples. They progenitor that VEGF difficulty improves the effectiveness of protected checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am exactly encouraged sooner than modus vivendi = 'lifestyle' of the responses to this treatment, and I am anticipating that with additional fact-finding this objective focus on forth a preferably treatment token a substitute alternatively of these patients," Raghav said. "I am chuffed looking payment the patients who are tickled pink to participate in clinical trials and muster look down on our facts of rare cancers."

Additional trials with larger numbers of patients are needed to validate these cram results, hawkshaw if this cure-all merge could be recumbent as frontline treatment or remodel surgical outcomes after these patients.

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